Effect of Ningshen Buxin Pill Combined with "Midnight-noon Ebb-flow Acupuncture" on Working Memory and Serum Hcy and NSE in Patients with Stroke and Depression

OBJECTIVE To explore the effect of Ningshen Buxin pill combined with "Midnight-noon Ebb-flow Acupuncture" on working memory and serum neuron enolase(NSE) and homocysteine(Hcy) in patients with stroke and depression. METHODS The 84 patients with acute ischemic stroke and depression from January 2019 to January 2020 were randomly divided into the TCM treatment group and the control group according to the random number table, 42 cases in each group. All patients were treated with routine internal medicine, the control group was treated with paroxetine hydrochloride oral antidepressant, and the treatment group was treated with Ningshen Buxin and "Midnight-noon Ebb-flow Acupuncture" on the basis of the control group. The clinical efficacy, the results of n-back test, the level of Hcy, NSE, myelin basic protein(MBP), 5-hydroxytryptamineand(5-HT) and norepinephrine(NE), the score of life quality were compared in the two groups. RESULTS The total effective rate of the treatment group(92.86%) was higher than that of the control group(76.19%)(P<0.05). After treatment, HAMD-24 score, NIHSS score, TCM syndrome score and serum NSE, Hcy and MBP in the two groups were significantly lower than those before treatment(P<0.05), the decrease of TCM treatment group was larger than that of control group(P<0.05). After treatment, the correct rate of n-back test in the two groups was significantly increased, and the reaction time was significantly decreased(P<0.05), and the correct rate was higher and the reaction time was lower in the TCM treatment group than that in the control group(P<0.05). After treatment, the level of 5-HT, NE and scores of physical health, mental health, environment, social relationship and quality of life in the two groups were significantly higher than those before treatment(P<0.05), and these in TCM treatment group were higher than in the control group. CONCLUSION Ningshen Buxin pill combined with "Midnight-noon Ebb-flow Acupuncture" can improve the neurological deficit, relieve depression and improve the function of memory in stroke patients with depression. The mechanism may be related to the decrease of Hcy and NSE.