Protective Effect of Quercetin on Cisplatin-induced Liver Injury Through NLRP Inflammatory Body Related Pathway

OBJECTIVE To explore the protective effect and biological mechanism of quercetin on cisplatin-induced liver injury through the NLRP inflammatory body related pathway. METHODS Before cisplatin treatment, mice were chronically administered with quercetin; the liver injury of mice was examined by serum biochemical analysis and liver histopathological analysis; the changes of apoptosis-related protein and NLRP3 inflammatory body-related protein were detected by Western blotting. RESULTS Quercetin could effectively prevent levels of serum alanine aminotransferase and aspartate aminotransferase and restoring liver histopathological changes, thereby effectively preventing liver injury injected by cisplatin. At the same time, quercetin could significantly inhibit the production of oxidative stress-related factors, reduce hepatocyte apoptosis, reduce Bax, Bad, cleaved caspase-3 and increase Bcl-2 expression. In addition, the NLRP3 inflammatory corpuscle pathway was inactivated by quercetin. CONCLUSION Quercetin inhibits cisplatin-induced liver injury in mice, which may be related to regulating NLRP3 inflammatory body-related pathways.