Meta Analysis of the Effect of Apolipoprotein E Gene Polymorphism on the Maintenance Dose of Warfarin in Chinese Population

OBJECTIVE To systematically evaluate the relationship between apolipoprotein E(APOE) gene polymorphism and warfarin maintenance dose in Chinese population. METHODS PubMed, EMBase, Cochrane Library, CNKI and Wanfang databases were searched by computer to collect studies about the relationship between APOE gene polymorphisms and warfarin maintenance dose in Chinese population. The data were extracted and the quality of literature were evaluated, and meta analysis was performed by using RevMan 5.3 statistical software. RESULTS A total of 11 studies, involving 2 320 patients were included. Meta analysis results showed that the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype was 30% higher than the APOE E3(E3/E3) genotype, and the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype was 43% higher than that of APOE E4(E3/E4, E4/E4) genotype, and the differences were statistically significant. The maintenance dose of warfarin for APOE rs7412 TT was significantly lower than that of CC and CT(P<0.05). CONCLUSION In Chinese population, the maintenance dose of warfarin required by APOE E2(E2/E2, E2/E3) genotype is significantly increased, and the maintenance dose of warfarin required by APOE rs7412 TT genotype is significantly decreased.