Study on the Potential of Gei Herba in the Treatment of Cardiovascular Diseases Based on Network Pharmacology and Molecular Docking Technology

OBJECTIVE To study the potential of Gei Herba in the treatment of cardiovascular disease by the method of network pharmacology. METHODS The main active components of Gei Herba were obtained through literature retrieval, the action targets of chemical components were found by PubChem, Swiss Target Prediction, TargetNet and other databases, and the potential targets related to diseases were screened by CTD database. The interaction of target proteins was analyzed by STRING, gene function and pathway analysis of target proteins by DAVID database, and the network was constructed and analyzed by Cytoscape software. The crystal structure of the related target was retrieved in the RCSB PDB database, and the molecular docking verification was carried out between the component and the target protein with the help of AutoDock software. RESULTS A total of 58 active components in Gei Herba were collected, which could act on 201 targets, including 73 targets related to cardiovascular diseases. Six pathways most related to cardiovascular disease were found, arachidonic acid metabolism, NF-kB signaling pathway, PI3K-Akt signaling pathway, insulin resistance, calcium signaling pathway and VEGF signaling pathway. CONCLUSION In this study, it is found that Gei Herba plays a role in the treatment of cardiovascular diseases mainly through inflammation, insulin resistance and regulating angiogenesis, which provides a scientific basis for its research direction and clinical application in the treatment of cardiovascular diseases.