Status and Prospect of PARP Inhibitors in Pancreatic Cancer

Pancreatic cancer is a kind of digestive tract malignant tumor, has the characteristics of fast progress and poor prognosis. Because of the complexity of the disease, the treatment of pancreatic cancer is not specific and effective, thereby identifying molecules mechanism that are associated with pancreatic cancer is important to explore new treatments of pancreatic cancer. Mutations in BRCA genes have been linked to the development of pancreatic cancer and can increase the risk of pancreatic cancer. PARP inhibitors which targets the BRCA gene showed a satisfactory curative effect. Through the mechanism of synthetic lethality and PARP-1-DNA capture, PARP inhibitors can produce inhibitory effect on pancreatic cancer which has the mutation of BRCA gene. Through the introduction of the application of BRCA gene, pancreatic cancer PARP inhibitor and its anti-tumor molecular mechanism PARP in pancreatic cancer, this paper aims to provide a new and reliable treatment scheme for pancreatic cancer.