Effect of Atorvastatin Calcium on Inflammation Control in Elderly Patients with Septic Shock

OBJECTIVE To explore the role of atorvastatin calcium in the inflammatory control of elderly patients with septic shock. METHODS A prospective randomized controlled clinical study was used to treat elderly patients with septic shock from January 2019 to December 2019 in intensive care unit(ICU), eastern section of Lihuili Hospital, Ningbo Medical Center. The patients were randomly divided into statin group and control group by random number table method. Control group received conventional comprehensive supportive treatment, statin group was added with statins on the basis of control group. The basic data such as age, gender, etiology, APACHE II were recorded. Inflammatory and systemic perfusion indicators: C-reactive protein, procalcitonin, temperature, white blood cell count, GAP, GAP ratio were observed and recorded before and 1, 3, 7 d after treatment. Patients’ 28-day survival rate, mechanical ventilation days, ICU hospitalization days, totally hospitalization days and other prognosis indexes were also recorded. RESULTS Eighty six patients were selected in the study ultimately. There was no significant difference of the basic data difference between two groups. Comparison of clinical indicators between two groups showed no difference before treatment and the 1 d after treatment. On the 3 d and 7 d after treatment, the improvement of clinical indicators in the statin group were better than that of the control group(P<0.05). Over time, there was an interaction between different groups and detection time points on clinical indicators(P<0.05), suggesting that the earlier application of atorvastatin calcium, the more improvement of the patient’s clinical indicators. Compared with control group, patients’ 28-day survival rate, mechanical ventilation days ICU hospital days and totally hospital days in statin group was significantly improved. CONCLUSION Atorvastatin calcium can improve the inflammation and systemic perfusion of the elderly patients with septic shock, which may improve the 28-day survival rate, reduce the mechanical ventilation time, length of stay in ICU and totally length of hospital days. The earlier taking of atorvastatin calcium, the more benefit to elderly patients with septic shock.