Research Progress of Pharmacokinetic Interactions of Proton Pump Inhibitors

OBJECTIVE To explore the progress of proton pump inhibitors pharmacokinetic interactions. METHODS To analyze and summarize the domestic and oversea research in the related area. RESULTS It systematically expounded that proton pump inhibitors affect the absorption of related drugs by increasing the pH in the stomach and inhibiting P-glycoprotein, and affect the metabolism of related drugs by inhibiting CYP2C19 and CYP3A4, and inhibiting the removal of related drugs by the kidney. The focus was on the interaction of proton pump inhibitors with digoxin, itraconazole, tyrosine kinase inhibitors, clopidogrel, warfarin, methotrexate, cisplatin and pemetrexed. CONCLUSION It should pay close attention to drug-drug interactions in clinical medication, and avoid the use of proton pump inhibitors in combination with such drugs, or select the proton pump inhibitors with lower interaction.