Clinical Efficacy of Tacrolimus in the Treatment of Nephrotic Syndrome and Its Influence on T Lymphocyte Subsets

OBJECTIVE To explore the clinical effect of tacrolimus on nephrotic syndrome and its influence on T lymphocyte subsets. METHODS A total of 105 patients with nephrotic syndrome admitted to Xingtai People's Hospital from December 2017 to December 2019 were selected as study subjects, and were divided into observation group(n=54) and control group(n=51) according to the random number table method. The control group was treated with prednisone tablet, while the observation group was treated with tacrolimus. The clinical treatment effect, T lymphocyte subsets, renal function indicators serum creatinine(Scr), blood urea nitrogen(BUN), serum albumin(ALB), 24 h urinary protein quantitative, serum triacylglycerol(TG), total cholesterol(TC), plasma fibrinogen(FIB), blood viscosity(PV) and adverse reactions were compared between the two groups. RESULTS After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group(87.04% vs 68.63%)(P<0.05). The levels of CD4⁺ and CD4⁺/CD8⁺ in the observation group were significantly higher than those before treatment and the control group, and CD8⁺ was significantly lower than that in the control group(P&llt;0.05). In the observation group, serum ALB was significantly higher than that before treatment and control group, while urinary protein quantification, Scr, BUN levels were significantly lower than that before treatment and control group(P<0.05). The levels of TG, TC, FIB and PV in the observation group were significantly higher than those in the control group(P<0.05). The total adverse reaction rate in the observation group was significantly lower than that in the control group (5.56% vs 19.61%)(P<0.05). CONCLUSION Tacrolimus treatment in patients with nephrotic syndrome can not only significantly improve the clinical efficacy, but also improve the level of T lymphocyte CD4⁺, CD8⁺, CD4⁺/CD8⁺ cells and blood lipid-related levels. It is safe, beneficial to the recovery of renal function and has high clinical value.