Analysis of Medication Rules of Traditional Chinese Medicine Patent Compound Based on Data Mining for Chronic Cholecystitis

OBJECTIVE To discuss the medication rule of traditional Chinese medicine patent compound for treating chronic cholecystitis. METHODS Search for Chinese medicine prescriptions for treating chronic cholecystitis through China patent database, establish an Excel data sheet to screen and process prescriptions, and use ancient and modern medical record cloud platform software to analyze the data. RESULTS The 170 compound prescriptions for the treatment of chronic cholecystitis were screened, the drugs were mainly cold and bitter, and the main meridian was liver meridian. The top 10 Chinese medicines used frequently were Radix Bupleuri, Glycyrrhizae Radix et Rhizoma, Curcumae Radix, Lysimachiae Herba, Artemisiae Scopariae Herba, Paeoniae Radix Alba, Radix Rhei et Rhizome, Toosendan Fructus, Scutellariae Radix, Corydalis Rhizoma. Association rules showed that the medicines were more compatible with Paeoniae Radix Alba-Radix Bupleuri, Paeoniae Radix Alba-Glycyrrhizae Radix et Rhizoma, Scutellariae Radix-Radix Bupleuri, Radix Rhei Et Rhizome-Lysimachiae Herba, Toosendan Fructus-Radix Bupleuri, Toosendan Fructus-Curcumae Radix, Toosendan Fructus-Lysimachiae Herba. Cluster analysis obtained 7 types of drug combinations. Complex network analysis obtained 30 core Chinese medicines and 3 groups of core drug compatibility. CONCLUSION The Chinese medicine patent compound for treating chronic cholecystitis is mainly bitter and cold, and mainly enters the liver meridian. The efficacy of the medicine is mainly to disperse stagnated liver Qi for promoting bile flow, clear away heat and dampness, regulate Qi and promote blood circulation, and purify the lower organs. The main drug compatibility is to relieve liver and soften liver, relieving spasm and pain, reconcile superficies and interior, clear heat and dampness, and disperse stagnated liver Qi for promoting bile flow. In terms of treatment, Sini Powder, Jinlingzi Powder, Dachaihu Decoction, and Yinchenhao Decoction are often used.