Progress of Clinical Research on the Drug Prevention and Treatment of Chemotherapy-induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy(CIPN) is a common clinical dose-limiting adverse drug reaction, which has not been properly resolved. Numerous clinical studies have been conducted on the toxicity with a variety of drugs, but most of the results have been unsatisfactory or conflicting. There are many reasons for that, in addition to the efficacy of the drug itself, the lack of a standardized evaluation tool has been a major limitation to trial success. This article starts with the symptom characteristics of CIPN, then the CIPN assessment tools widely used in clinical practice are described and evaluated, finally comprehensive reviews the kinds of drugs that benefit from prevention and treatment of CIPN in clinical research, and gives corresponding recommendations based on the evidences.