Research Progress of Neoantigen in Precision Tumor Immunotherapy

Personalized precision medicine is vital part of tumor immunotherapy. Neoantigen is kind of epitope peptides on major histocompatibility complex(MHC) which is specially located on surface of tumor cells. They are a kind of antigenic peptides with specific amino acid sequence variation, which are encoded, transcribed and translated by mutated somatic genes. There are a thousand Hamlets in a thousand people's eyes, so as the tumor mutations. Neoantigen is one of the important ways to realize "personalized" therapy. Neoantigen therapy is a supplement to represented by PD-1/PD-L1 antibody and CAR-T. This article reviews the discovery process of neoantigen, the application of neoantigen vaccine in tumor immunotherapy and clinical trials.