Optimization of Preparation Technology of Captopril Pulse Capsule

OBJECTIVE To optimize the process of preparing pulse capsules with captopril as a model drug, and study the release mechanism in vitro and pharmacokinetics in vivo of pulse capsules. METHODS Impermeable capsules, tablets, wax dissolution tablets and embolic tablets were prepared and assembled into captopril pulse capsules. The preparation process was optimized by single factor test and star design. The pharmacokinetic study in rabbits was carried out with captopril ordinary tablets as a control. RESULTS The AUC and average residence time(MRT) of captopril pulse capsules were significantly different from those of captopril pulse tablets. MRT and time lag of captopril pulse capsules were 2.39 times and 10.66 times higher than those of common tablets respectively. CONCLUSION According to C_max and AUC data(double one-sided t-test and confidence interval method), it is inferred that captopril pulse capsules had obvious time delay compared with ordinary tablets.