Effects of α Lipoic Acid-Assisted Olmesartan Medoxomil on Serum miR-150-5p and miR-155-5p Expression in Patients with Diabetic Nephropathy

OBJECTIVE To explore the effect of α lipoic acid-assisted olmesartan medoxomil on patients with diabetic nephropathy and the expression of serum miR-150-5p and miR-155-5p. METHODS The 144 patients with diabetic nephropathy admitted to Zhebei Mingzhou Hospital from January 2016 to January 2019 were enrolled. The patients were divided into control group and observation group according to the random number table method, 72 cases in each group. The patients in both groups were treated with olmesartan medoxomil based on routine treatment. The observation group was treated with α lipoic acid on the basis of the control group. The clinical efficacy of the two groups was compared, as well as the blood glucose and fluctuation levels and oxidation level before and after treatment, high-sensitivity C-reactive protein(hs-CRP), urinary protein excretion rate(UAER), changes in urinary β2 microglobulin(β2-MG), serum miR-150-5p and miR-155-5p. RESULTS The total effective rate of observation group was 86.11%. The total effective rate of the control group was 72.22%. The total effective rate of the observation group was higher than that of the control group. The difference was statistically significant(P < 0.05). The blood glucose and fluctuation levels, oxidation level, hs-CRP, UAER, and β2-MG in the observation group were significantly better than control group(all P < 0.05). The expression levels of serum miR-150-5p and miR-155-5p after one month were lower than those before treatment(P < 0.05), and the reduction of serum miR-150-5p and miR-155-5p expression in the observation group was significantly better than that in the control group(P < 0.05). CONCLUSION Treatment of α lipoic acid-assisted olmesartan medoxomil can improve the clinical efficacy of early diabetic nephropathy and improve peripheral blood glucose levels, reduce blood glucose fluctuations, alleviate the body's oxidation reaction, reduce inflammation, decrease serum level of miR-150-5p and miR-155-5p, and it is worthy further study and promotion.