Prognostic Value and Immune Infiltration Analysis of Transcription Factor FOXF1/F2/J1/M1/O1/O3/P3 in Lung Adenocarcinoma

OBJECTIVE To elucidate the effect of Forkhead box(FOX) transcription factor family on the prognosis of lung adenocarcinoma through the expression of FOX transcription factor family in lung adenocarcinoma. METHODS The expression of FOX family at transcriptional level was analyzed by GEPIA database; the survival of FOX family was analyzed by Kaplan-Meier plotter database; the mutation probability of FOX family members was analyzed by cBioPortal database, and the protein interaction network was constructed; the pathway enrichment analysis of FOX family members was performed by WebGestalt database; and the immune infiltrating lymphocytes of these key genes in lung adenocarcinoma were analyzed by Timer database. RESULTS GEPIA database showed that the expression of FOXA1/A3/J1/M1/P3 was significantly higher than that of normal tissues, while the expression of FOXF1/F2/O1/O3 in lung adenocarcinoma was significantly lower than that of normal tissues(P<0.05). The increase of FOXJ1/M1/P3 mRNA level and the decrease of FOXF1/F2/O1/O3 mRNA level were significantly correlated with the overall survival rate(P<0.05). The level of immune infiltration in lung adenocarcinoma was correlated with the expression of FOXF1/F2/O1/P3. CONCLUSION FOXF1/F2/J1/M1/O1/O3/P3 is a potential marker for poor prognosis of lung adenocarcinoma. FOXP3 is related to the immune infiltration of lung adenocarcinoma and may be involved in the regulation of CD4 cells and B cells in lung adenocarcinoma.