Meta-analysis of Phlebitis Caused by Different Administration Methods of Alprostadil Microsphere Carrier Preparation

OBJECTIVE To evaluate the difference of the occurrence of phlebitis caused by different administration methods of the alprostadil microsphere carrier preparation by using the method of meta-analysis, and to provide evidence-based reference for clinical application. METHODS To search the CNKI, VIP, Wanfang, Chinese Biomedical Literature Database, EMbase, Pubmed, Cochrane Library, collected literatures about phlebitis caused by alprostadil microsphere carrier preparation in different routes. The screening conditions were established and the literature was screened. After evaluating the quality according to the manual of Cochrane system evaluator, the effective data extracted were meta-analyzed by RevMan 5.2 statistical software. RESULTS Twenty three randomized cotrolled trial(RCT) studies involving 3 165 patients were included. Meta analysis showed that intravenous injection of alprostadil microspheres was more likely to increase the incidence of phlebitis than intravenous dripRR=1.92, 95%CI(1.17, 3.17), P=0.01, but there was no difference in the incidence of phlebitis caused by intravenous injection of alprostadil microspheres and off-lable drug useRR=1.35, 95%CI(0.69, 2.64), P=0.38. There was no significant difference in the incidence of phlebitis caused by intravenous infusion of alprostadil microspheres and off-lable drug useRR=0.52, 95%CI(0.17, 1.62), P=0.26, but the incidence of phlebitis caused by intravenous infusion of alprostadil microspheres was lower than that of intravenous pumpRR=0.46, 95%CI(0.31, 0.67), P<0.000 1. According to meta analysis, the incidence of phlebitis caused by alprostadil microspheres used common infusion set was significantly higher than that of fine filtration infusion setRR=0.18, 95%CI(0.13, 0.25), P<0.000 01, and the difference used common infusion set was statistically significant. Meta analysis showed that the incidence of phlebitis by slow intravenous injection of alprostadil microsphere carrier was significantly higher than that of rapid intravenous injectionRR=0.37, 95%CI (0.21, 0.67), P=0.001 0. CONCLUSION The incidence of phlebitis caused by alprostadil microsphere carrier preparation used rapid intravenous injection or fine filtration infusion set was low, while used intravenous injection is higher than intravenous drip, used intravenous pump is higher than intravenous infusion. There is no difference of the incidence of phlebitis caused by alprostadil microsphere carrier preparation according to the instructions or off-lable drug use.