Comparison of Graphite Furnace Atomic Absorption Spectrometry and ICP-MS for Determination of Aluminum in Compound Amino Acid Injection

OBJECTIVE To compare the determination methods for aluminum residual in Compound Amino Acid injection by graphite furnace atomic absorption spectrometry(GFAAS) and inductively coupled plasma-mass spectrometry(ICP-MS). METHODS The content of aluminum in 59 batches of Compound Amino Acid injection produced by 12 pharmaceutical companies was determined by GFAAS with polarized Zeeman background correction and ICP-MS. RESULTS There was a good linear relationship of GFAAS in the concentration range of 5-40 ng·mL^-1(r=0.995 3), and the average recovery was 100.1%, RSD=4.80%(n=9). There was a good linear relationship of ICP-MS in the concentration range of 5-100 ng·mL^-1 (r=0.999 9), and the average recovery was 104.7%, RSD=1.75%(n=9). CONCLUSION The measured values of the two methods are basically the same. There is a significant difference in residues of aluminum between the products from different manufacturers and it is necessary to control residual aluminum in Compound Amino Acid injection.