Treatment of a Case of Severe Ulcerative Colitis with Glucocorticoid Resistance Patient by Cyclosporine Conversion

OBJECTIVE To explore the role of clinical pharmacists in the treatment of severe ulcerative colitis with glucocorticoid resistance by cyclosporine conversion. METHODS Clinical pharmacists fully participated in the treatment of a case of severe ulcerative colitis with glucocorticoid resistance, and assisted the physician in the selection of switching drugs, the dosage was adjusted according to the patient's condition change and results of blood concentration monitoring of cyclosporine, to monitor clinical efficacy, drug interactions and adverse reactions, and to provide medication education for patients. RESULTS Cyclosporine was selected as the conversion drug, and the dose of cyclosporine was adjusted to ensure that its blood concentration remained within the effective therapeutic window, so as to avoid adverse reactions, and the patient's condition improved and discharged; the patient was given a detailed and comprehensive application education of cyclosporine, and the patient compliance with medication was improved. CONCLUSION Clinical pharmacists optimize the drug therapy for patients with severe ulcerative colitis with glucocorticoid resistance, to promote rational drug use, and provide a reference for the drug treatment plan of similar clinical patients, and embody the important value of clinical pharmacists.