Bibliometric Analysis of Blood Concentration Monitoring Research in China

OBJECTIVE To analyze the development of the domestic blood drug concentration monitoring research by means of bibliometrics. METHODS Iterature on monitoring blood drug concentrations was searched by CNKI, Wanfang database, Weipu Chinese scientific journal database and Web of Science citation database from the establishment database to May 2019, screening out the research that conform to the standard, the publishing time, periodical, author, unit and keyword of the included literature were extracted and sorted out by BICOMB 2.0 software, and the co-occurrence matrix and lexical matrix for keywords were generated. NetDraw 2.118 and gCLUTO software in Ucinet 6.0 software were used to draw network diagram and cluster analysis of keywords. RESULTS A total of 3 642 Chinese articles related to blood concentration monitoring were searched, and 1 267 articles were finally included. The relevant research first appeared in 1983. The number of published journals, authors and units were numerous but very uneven. The 106 articles in English were included, and relevant studies were first published in 1999. There were 1 187 keywords in the research literature. According to the high frequency keywords, the research was divided into four topics. The research hotspots were mainly on immunosuppressants, antitumor drugs, psychotropic drugs, antibiotics, cardiovascular drugs and so on. CONCLUSION Domestic studies on blood concentration monitoring are at an increasing stage, with more researchers and institutions involved but with uneven distribution and fewer prolific authors and research institutes. This requires Chinese pharmaceutical workers to strengthen exchanges and cooperation in various regions, improve the level of research in this field, expand the scope of research, and achieve comprehensive and accurate monitoring.