Study on Anti-inflammatory, Analgesic and Anti-pruritus Effects of Meilianjing Gel

OBJECTIVE To study anti-inflammatory, analgesic and anti-pruritus effect of Meilianjing gel. METHODS The anti-inflammatory effects of Meilianjing gel were investigated by the tests of using egg white solution to induce foot swelling in mice, carboxymethylcellulose sodium(CMC-Na) to induce leukocyte migration in subcutaneous balloon in mice, and cotton ball to induce granuloma in mice. The analgesic effect of Meilianjing gel was investigated by the test of acetic acid-induced writhing reaction in mice. The inhibition effect of Meilianjing gel on pruritus in mice induced by dextran-40 was investigated. RESULTS Each dose group of Meilianjing gel could inhibit the toe swelling of mice induced by egg white liquid. Each dose group could reduce the scratching frequency of mice within 30 min after itchiness, but there was no statistical difference. The high-dose group could significantly inhibit the leukocyte migration in the subcutaneous air sac of mice 3 h after the inflammation induced by CMC-Na(P<0.05), while the high-dose and medium-dose groups could significantly inhibit the leukocyte migration in the subcutaneous air sac of mice 6 h after the inflammation induced by CMC-Na(P<0.05). The high-dose group could significantly promote granulation tissue hyperplasia induced by cotton balls in mice(P<0.01), and the high-dose group could reduce the number of writhing induced by acetic acid in mice(P<0.05). CONCLUSION Meilianjing gel has obvious anti-inflammatory and analgesic effect, and has anti-pruritus effect.