Advances in the Application of Point-of-care Testing in Therapeutic Drug Monitoring

Therapeutic drug monitoring is used to measure the concentration of pharmaceutical drug in patients' bio-fluids at certain time intervals to allow a timely control of their dosage. This practice allows for rapid medical intervention in case of toxicity-related issues and adjustment of dosage to better fit the therapeutic demand. Point-of-care testing(POCT) can be used in therapeutic drug monitoring to measure the concentration of drug simply rapidly and sensitively. It is convenient for personalized drug therapy for clinical guidance and reduce adverse reactions of drugs. Some POCT assays has been developed and studied for therapeutic drug monitoring in recent years by foreign researchers, but few in domestic. In order to get more information about the application of POCT in therapeutic drug monitoring, for understanding more application of drug concentration determination, the application of this method is reviewed from the aspect of therapeutic drug monitoring in this article.