Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery

OBJECTIVE To explore the effects and safety of human albumin in burn shock recovery, and to provide a theoretical basis for its rational use. METHODS The retrospective case-control study was conducted. Patients who admitted to the burn ward and needed fluid resuscitation during the period of January 2011 to December 2018 in Second Affiliated Hospital, Zhejiang University School of Medicine were identified. Patients were divided into two groups according to the severity of burns, the patients with a 20%50% constituted the severest burn group, and albumin resuscitation was divided into albumin group and non-albumin group. The primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications. RESULTS In the patients with 20%50%, there were no significant differences in mortality, hospital stay, ventilator supporting, fluid use, and complications between the albumin group and the non-albumin group; the number of ventilator days in the albumin group was higher than that in the non-albumin group(P=0.003), but the multivariate analysis of variance showed that it had no association with the albumin use. During the patient's hospitalization, there was no significant adverse effects caused by the use of human albumin. CONCLUSION In the patients with burn shock resuscitation, the use of human albumin don't improve the clinical outcomes, and there is no obvious adverse reactions occurred.