Research Progress on the Relationship of Peripheral 5-Hydroxytryptamine System and Diabetes or Its Complications

Diabetes mellitus and its complications become serious threat to human health. Due to the ambiguous mechanism of diabetes pathogenesis, the development and promotion of anti-diabetes drugs have greatly hindered. Clinical and animal experimental results suggest a close association between 5-hydroxytryptamine(5-HT) and the occurrence and development of diabetes. With the deepening of research, the peripheral 5-HT system has shown its potential as an important target for curing diabetes. First of all, peripheral 5-HT in the occurrence and development of diabetes and its complications is described, and then the mechanism of 5-HT regulating diabetes is discussed, then 5-HT receptors which associated with diabetes complications are systematically summarized, finally, the prospect of how to use drugs to prevent and cure diabetes through 5-HT system is put forward.