Discussion on the Rule of Traditional Chinese Medicine in the Treatment of Gastric Precancerous Lesions Based on Association Rules and Factor Analysis

OBJECTIVE To explore the regularity of traditional Chinese medicine in the treatment of precancerous lesions of gastric cancer. METHODS Precancerous lesions were used as the main topic, prescriptions recorded in relevant journals on CNKI(from January 1, 2009 to December 31, 2018) were searched, and a database was established for statistical analysis. Using Excel 2013, SPSS Modeler 14.1 and SPSS Statistics 19.0 statistical software, association rule analysis, factor analysis and system clustering analysis were conducted for the included TCM medicines. RESULTS Eighty three periodical literatures met the standards, and were included, including 167 kinds of traditional Chinese medicine, with a total frequency of 1 676 times. Among the 167 herbs, included 49 herbs with frequency≥5, 22 high-frequency drugs with frequency≥15, Hedyotis diffusa was the most common used(48, 6.45%). Efficacy classification was mainly composed of tonic-deficiency drugs(207, 27.82%), heat-clearing drugs(171, 22.98%) and blood-activating and stasis-relieving drugs(111, 14.92%). The medicinal properties were mainly warm(273, 36.94%), cold(233, 31.53%) and calm(193, 26.12%), while the taste was mainly bitter(420, 36.90%), sweet(385, 33.83%) and pungent(266, 23.37%). Classification by spleen, stomach, liver channel was in the majority. In the analysis of association rules, 10 drug pairs with the highest association strength were found, 8 common factors were extracted from the factor analysis, and they were classified into 3 categories based on the systematic clustering analysis.CONCLUSION The traditional Chinese medicine treatment of precancerous lesions of gastric cancer is mainly filled with tonic-deficiency drugs, with the most frequent used of heat-clearing drugs, blood-activating and stasis-relieving drugs, and the combination with the syndrome of regulating Qi drugs, water infiltration and dampening drugs.