Clinical Characteristics of Sodium Valproate Blood Concentration in Epilepsy Patients

OBJECTIVE To explore the relationship between sodium valproate blood drug concentration and clinical manifestations such as the patient's basic situation, dosage form, usage and dosage, to provide a reference for individualized medication plan. METHODS Enzyme multiplied immunoassay technique was used to determine the plasma concentration of sodium valproate, SPSS software was used to make statistics on the data, and single factor analysis was used to evaluate the relevant factors and characteristics that affect the plasma concentration. RESULTS The average blood concentration of sodium valproate in patients in Suining Central Hospital was higher than the standard concentration. The daily dose, combined use of carbapenems and liver drug enzyme inducer were related to the influence of the blood concentration of sodium valproate in patients with epilepsy factor. Although there was no significant difference in the compliance rate of different dosage forms, the compliance rate of sustained-release tablets and injections was significantly higher than that of ordinary tablets. The compliance rate of patients with normal liver function or mild injury was 51.11%, which was significantly higher than that of patients with severe injury. The adverse drug reactions in the group with blood concentration >100 mg·L^-1 were significantly higher than those in the group with blood concentration <50 mg·L^-1 and 50-100 mg·L^-1. CONCLUSION The blood concentration of sodium valproate in hospitalized patients is affected by many factors. Clinical pharmacists should give recommendations for dose adjustment and preventive measures according to relevant risk factors, which can help reduce adverse drug reactions.