Research Progress of the Accuracy of Propofol Target-controlled Infusion

Target-controlled infusion(TCI) is a computer-controlled drug infusion technique that calculates the rate of drug infusion to maintain target concentration based on pharmacokinetic parameters. Propofol TCI is widely used in clinical anesthesia, and can perform relatively accurate anesthesia for majority patients. However, in some cases, the TCI system can't accurately predict the actual plasma concentration, which in turn affects the doctor's judgment on the actual plasma concentration. The effects of propofol TCI accuracy on the choice of pharmacokinetic model, the difference of inter-individual pharmacokinetics and the change of perioperative pathophysiological state are noted to remind anesthesiologists to the difference in the pharmacokinetics of propofol in these situations. The anesthesiologist should be alert to the adverse reactions caused by the deviation of TCI administration, and adjust the target concentration and medication regimen according to other monitoring indicators.