Study on the Reasonable Using Time of Sofren Injection After Drug Allocation in PIVAS

OBJECTIVE To investigate the reasonable using time of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection after drug allocation in pharmacy intravenous admixture services(PIVAS). METHODS Sofren injection was allocated with 5% glucose injection and 0.9% sodium chloride in PIVAS, and the changes were evaluated in appearance, pH values and insoluble particle in 6 h at room temperature. The stability of salidroside and tyrosol which were the main components of Sofren injection in 6 h was determined by HPLC. RESULTS After the allocation of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection, its appearance, pH values and insoluble particles met the requirements of the Chinese Pharmacopoeia 2015 Edition within 6 h at room temperature. Salidroside and tyrosol were stable within 6 h. CONCLUSION The reasonable using time of Sofren injection with 5% glucose injection and 0.9% sodium chloride injection after drug allocation in PIVAS is 6 h.