Research on Adjunctive Therapeutic Effects and Mechanism of Bushen Tiaochong Decoction in Polycystic Ovary Syndrome

OBJECTIVE To investigate clinical efficacy and mechanism of Bushen Tiaochong Decoction adjuvant ovulation induction in treating polycystic ovary syndrome(PCOS). METHODS One hundred PCOS cases conforming diagnostic criteria in the First Affiliated Hospital of Xinxiang Medical University were selected by clinical randomized controlled trial from January 2016 to December 2018. They were divided into observation group and control group by random number table, 50 cases in each group. Patients in the control group was treated with ethinylestradiol cyproterone combined with letrozole, while patients in the observation group were given the treatment of Bushen Tiaochong Decoction on the basis of the treatment of the control group. The total course of treatment was 6 menstrual cycles. Then the clinical data of the two groups were recorded, and fat cytokines, sex hormones, oxidative stress and other indicators were measured before and after treatment. RESULTS After treatment, the visfatin, leptin, testosterone, luteotropic hormone(LH), follicle-stimulating(FSH), LH/FSH, malondialdehyde levels and abortion rate the in observation group were significantly lower than those of the control group (P<0.05); adiponectin levels, estradiol levels, superoxide dismutase, glutathione peroxidase levels, ovulation rate and pregnancy rate were significantly higher than those of the control group(P<0.05). CONCLUSION Bushen Tiaochong Decoction has a good adjuvant therapeutic effect on PCOS, which can regulate the level of sex hormones effectively, improve oxidative stress and alleviate insulin resistance.