Systematic Review on Efficacy and Safety of Baclofen in the Treatment of Intractable Hiccup

OBJECTIVE To systematically review the efficacy and safety of baclofen in the treatment of intractable hiccup. METHODS CNKI, Wangfang database, VIP, Pubmed, Embase and the Cochrane library were searched to collect randomized control trials(RCTs) regarding the treatment of intractable hiccup by baclofen. Two reviewers independently screened literatures, extracted data and assessed the risk bias of included studies according to the inclusion and exclusion criteria. Then, meta-anaysis was performed using Revman 5.3 software. RESULTS Sixteen RCTs involving 889 patients were included. The results of meta-analysis showed that, compared with control group, baclofen was more effective for the treatment of intractable hiccupRR=1.43, 95%CI(1.27, 1.59), P<0.000 01, had rapider onsetSMD=-3.67, 95%CI(-5.98, -1.37), P=0.002, and shorter courseWMD=-2.88, 95%CI(-4.37, -1.39), P=0.000 1. There was no statistically significant difference in the incidence of adverse reactionsRR=0.64, 95%CI(0.43, 0.96), P=0.03 between two groups. CONCLUSION Baclofen is effective and safe in the treatment of intractable hiccup according to currently available evidence.