Studies on the Optimal Bacteriostatic Concentration of Bacteriostat and the Evaluation of Bacteriostatic Efficacy of Carteolol Hydrochloride Eye Drops
-
Graphical Abstract
-
Abstract
OBJECTIVE To investigate the optimal concentration of benzalkonium chloride that added to carteolol hydrochloride eye drops. METHODS According to the minimum inhibitory concentration of benzalkonium chloride. The initial bacteriostatic effect of carteolol hydrochloride eye drops with the concentration of 5-70 mg·mL-1 was investigated, and the appropriate amount of bacteriostatic agent was selected. In addition, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger spore suspension were added to test the survival of the above microorganisms in different periods of time. RESULTS Benzalkonium chloride 40 μg·mL-1 had a good inhibitory effect on the growth of 5 challenging microorganisms and it was the lowest effective dose. CONCLUSION Benzalkonium chloride 40 μg·mL-1 can be used as optimal concentration of bacteriostatic agent in carteolol hydrochloride eye drops.
-
-
DownLoad: