Rationality Discussion of Off-label Drug Use in Pseudomonas Aeruginosa Preparation and Cases Analysis

OBJECTIVE To collect and analyze the rationality of off-label drug use in hospitalized patients who used the pseudomonas aeruginosa preparation in First Affiliated Hospital of Kunming Medical University. METHODS Based on the drug specification, analyzed the rationality of the typical cases by searching relevant data at home and abroad, such as guidelines and literature. RESULTS A total of 1 349 cases were summarized, 848 cases of which were off-label, accounting for 62.86%, including 237 cases for indications beyond the instructions and 848 cases for dosage or drug delivery route beyond the instructions. CONCLUSION Spraying the high-dose pseudomonas aeruginosa preparation on the operative wound during the cancer surgery depended on scientific theories and clinical trials, and the use of pseudomonas aeruginosa injection in rhinosinusitis surgery without evidence medical evidence shall be used cautiously.