Clinical Efficacy of Dipyridamole Combined with Shuxuening in the Treatment of Acute Cerebral Infarction with Ultrathrombolytic Time Window

OBJECTIVE To investigate the clinical efficacy of dipyridamole combined with Shuxuening in the treatment of acute cerebral infarction with ultrathrombolytic time window(onset time>6 h) and its effect on coagulation index. METHODS From January 2018 to January 2019, according to the method of random control, 104 patients with acute cerebral infarction in Wuhan Wuchang Hospital were divided into control group(52 cases) and observation group(52 cases). Both groups received routine treatment. The control group was treated with Shuxuening, the observation group was treated with dipyridamole combined with Shuxuening. The clinical efficacy and incidence of adverse reactions were compared between the two groups. The coagulation indexFG, TT, APTT amd PT, NIHSS and Fugl-Meyer scores were also compared between the two groups before and after treatment. RESULTS The total effective rate of the observation group was 92.31%, which was significantly higher than that of the control group(76.92%). The difference was statistically significant(P=0.03, χ²=4.73). 24 h and 48 h after treatment, the level of FG in the observation group were significantly lower than those in the control group, the TT, APTT and PT of were significantly higher than those of the control group(P<0.01). After treatment, the score of NIHSS in the observation group was significantly lower than that in the control group. The Fugl-Meyer score was significantly higher than that in the control group(P<0.01). During the treatment, the heart rate slowed down, nausea and vomiting, gastrointestinal hemorrhage and other adverse reactions occurred in both groups, there was no significant difference in the incidence of adverse reactions between the two groups. CONCLUSION The effect of dipyridamole combined with Shuxuening in the treatment of acute cerebral infarction with super thrombolytic time window is better than that of routine therapy. It can improve the hemorheological indexes of patients and protect the neurological and motor functions of patients. And it has high safety and is worth popularizing and using in clinic.