Advances in Research on cAMP/PKA/CREB Signaling Pathway Regulating Tissue and Organ Cell Fibrosis and Intervention Effect of Traditional Chinese Medicine

Cyclic adenosine monophosphate(cAMP) phosphorylated cAMP counter-binding protein(CREB) by activating cAMP-dependent protein kinase A(PKA), thereby regulating gene transcription and is widely involved in the learning and memory processes of the nervous system. In recent years, studies have shown that the cAMP/PKA/CREB signaling pathway is involved in the fibrosis process of tissues and organs. During the repair process of tissue and organ cells after injury, the abnormal proliferation of extracellular matrix is fibrosis, and fibrosis can reduce the function of liver, lung, kidney and heart. Traditional Chinese medicine has unique advantages in the treatment of chronic and complex diseases such as fibrosis, and regulation of cAMP/PKA/CREB signaling pathway is one of the mechanisms for its prevention and treatment of tissue and organ cell fibrosis.