Effects of Xinmailong Combined with Bisoprolol on Serum TGF-β and ICAM-1 Expression in Coronary Heart Disease Patients with Heart Failure

OBJECTIVE To explore the effect of Xinmailong combined with bisoprolol on the expression of transforming growth factor-β(TGF-β) and serum intercellular cell adhesion molecule-1(ICAM-1) in patients with coronary heart disease and heart failure. METHODS One hundred and two patients with coronary heart disease and heart failure who were admitted to the author's hospital from March 2016 to April 2017 were enrolled and divided into observation group and control group via random number table method, each 51 cases. The control group received oral administration of bisoprolol fumarate tablets on the basis standard care. The observation group was treated with Xinmailong injection intravenously additionally. After 10 d of treatment, serum B-type natriuretic peptide(BNP), serum high-sensitivity C-reactive protein(hsCRP), vascular endothelial growth factor(VEGF), serum TGF-β, ICAM-1 level and cardiac functions were detected, and adverse reactions appeared in treatment were recorded. RESULTS After treatment, effective cases(47 cases, 92.2%) in the observation group was significant higher than control group(39 cases, 76.5%)(P<0.05). Serum BNP, hsCRP levels were significantly lower in the two groups compared with before treatment, and observation group were significantly lower than those in the control group(P<0.05). LVEDD was significantly lower, LVEF, CO and CI were significantly higher compared with before treatment in the two groups(P<0.05). Additionally, observation group present a better cardiac function. Serum TGF-β and VEGF levels were significantly higher and serum ICAM-1 levels were significantly lower in the two groups than before treatment. Observation group displayed better improvement in TGF-β and ICAM-1 compared with control group(P<0.05). The patients with adverse reactions in the two groups showed no significant difference. CONCLUSION In the treatment of coronary heart disease heart failure, Xinmailong combined with bisoxolol can effectively improve the level of serum TGF-β, reduce the expression of serum ICAM-1, reduce myocardial inflammatory reaction, control ventricular remodeling, and effectively improve cardiac function with high safety.