Effect of Diosmin on Pharmacokinetics of Glibenclamide in Rats

OBJECTIVE To investigate the effect of diosmin on the pharmacokinetics of glibenclamide in rats. METHODS Twelve SD rats were randomly divided into the diosmin group and control group, which were administrated respectively with diosmin(325 mg·kg^-1, ig, qd) and CMC-Na solution for 7 d. Glibenclamide was given to the rats by intragastric administration. The plasma concentration of glibenclamide was determined. Main pharmacokinetic parameters were calculated by DAS 2.0 and analyzed statistically. RESULTS Compared with the control group, the C_max of the diosmin group was significantly lower(P<0.05), t_max was significantly shortened(P<0.05), the AUC_(0→t) and AUC_(0→∞) of glibenclamide were significantly lower(P<0.05), and the CL was significantly increased(P<0.05). There were no significant difference between the two groups of t_1/2. CONCLUSION Diosmin can affect the pharmacokinetics of glibenclamide in rats. To avoid the potential risk of drug interaction, the plasma concentration of glibenclamide shall be monitored when combination.