Clinical Observation of Ebastine Combined with Portulacae Herba in the Treatment of Atopic Dermatitis

OBJECTIVE To analyze the clinical effect of ebastine combined with Portulacae Herba in the treatment of atopic dermatitis(AD) and its effect on miR-186-5p and miR-409-3p expression. METHODS One hundred and twelve cases of AD patients from Oct.2014 to Oct.2017 in Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University were randomly divided into control group and observation group, 56 cases in each group. The control group was given ebastine orally, while the observation group was treated with Portulacae Herba external application additionally based on the control group. The symptom scores and clinical efficacy were compared before treatment, 2 and 4 weeks after treatment. The levels of Th17/Treg, IL17 in peripheral blood and the expressions of miR-186-5p and miR-409-3p in skin specimens at lesion margins were compared before and after treatment. RESULTS Before treatment, all indexes of two groups showed no significant difference. After 2 and 4 weeks of treatment, the symptom score of the observation group was significantly lower than that of the control group(P<0.05). The total effective rates of the observation group were 66.07% and 80.36% respectively at 2 and 4 weeks of treatment, which were significantly higher than those of the control group(35.72% and 57.14%, P<0.05). After treatment, Th17%, Th17/Treg and IL-17 in the two groups were decreased significantly, and that in the observation group was significantly lower than that in the control group(P<0.05), and the expression of miR-186-5p and miR-409-3p of two groups were decreased significantly, and that in the observation group was significantly lower than that in the control group(P<0.05). CONCLUSION Ebastine combined with Portulacae Herba can effectively improve the clinical symptoms of AD, improve the curative effect, down-regulate the expression of miR-186-5p and miR-409-3p in skin, reduce the expression of Th17/Treg in serum, and improve the inflammatory state.