Effect of Acipimox Combined with Clopidogrel on Blood Lipid and Carotid Plaque in Patients with Hyperlipidemia

OBJECTIVE To investigate the clinical effect of acipimox combined with clopidogrel in the treatment of hyperlipidemia and carotid plaque. METHODS Sixty six patients with hyperlipidemia and carotid plaque were randomly divided into acipimox group and acipimox+clopidogrel group. Acipimox group was given acipimox 0.25 g, bid, orally, acipimox+clopidogrel group was given acipimox 0.25 g, bid, orally and clopidogrel 75 mg, qd, orally. Treatment course of 2 groups lasted for 8 weeks. The plasma level of TC, TG, HDL-C, LDL-C, IMT, parameters of hemorheology, TNF-α, IL-1 and IL-6 were observed in 2 groups before and after treatment. RESULTS TC, TG, HDL-C, LDL-C, IMT, parameters of hemorheology, TNF-α, IL-1 and IL-6 had no statistical significance between 2 groups before treatment. TC, LDL-C, carotid plaque area, plasma fibrinogen, TNF-α and IL-6 of 2 groups after treatment were significantly lower than before, and those of acipimox+clopidogrel group were significantly lower than acipimox group(P<0.05). IMT of 2 groups was improved, but no statistical significance between 2 groups compared with before treatment. CONCLUSION Acipimox combined with clopidogrel can significantly improve blood lipids in patients with hyperlipidemia, significantly reduce carotid plaque in patients, and improve the patient’s condition, which has clinical diagnosis and treatment value.