Research Progress of New Methods for Biomarker Detection

Biomarker is an important indicator for clinical diagnosis, classification, and prognosis of diseases. In recent years, biomarker detection methods have been developed rapidly. On the basis of the antigen-antibody binding principle, the traditional detection methods have been improved combined with the changes of light and electricity and the specificity and sensitivity have been increased satisfactorily. In the field of recognition element, molecular imprinting, aptamer and single-domain antibodies have been developed for improving the stability and reproducibility of detection methods. This article will review the current biomarker detection methods and prospects for their future development.