Control Practices and Intervention Effect Analysis of Management Platform for Rational Drug to Post-operative Use of Non-steroidal Anti-inflammatory Drugs with Injection

OBJECTIVE To establish and apply the rule of rational drug use of non-tubular anti-inflammatory drugs for injection, conduct pre-prescription and manual audits, and promote rational drug use through the management platform software of rational drug use. METHODS Based on the management platform of rational drug use, instructions, expert consensus and other evidence to precision database and prescription grading management of lornoxicam, flurbiprofen, ketolonine aminosine injection for injection. By randomly selecting 100 surgical patients using the three drugs before (July 2018-September 2018, control group) and after (October 2018-December 2018, intervention group) using the Rational Drug Administration Platform, to evaluate the rationality of the rationality of the indications, the period of treatment, drug delivery way, dose, dosing frequency, combination and adverse drug. To evaluate, analyze and compare for using numbers, defined daily doses and amount used for using the three drugs during three months before and after intervention. RESULTS After the operation of the platform, the proportion of unreasonable medical advice decreased significantly, with a decrease of 69.3%, from 38.54% before intervention to 11.67% after intervention. The incidence of inappropriate route of administration, inappropriate dose, too long course of treatment, inappropriate combination of drugs and inappropriate drug selection in the intervention group was significantly reduced (P<0.01). There was no significant difference between the two groups in the unknown use indications, choice of solvent inappropriate, and the adverse reactions occurred. The number of users, defined daily doses and amount used about the three kinds of drugs were significantly reduced after intervention(P<0.01 or P<0.05). CONCLUSION The application of rational drug use management platform can provide intelligent, precise and individualized service to clinical, improved audit efficiency, standardize the use of non-steroidal anti-inflammatory drugs for injection from the source, and promote the active exploration to new work mode of the pharmacist as well as the level of rational drug use in hospital.