Study on the Mechanism of Astragalus Membranaceus in the Treatment of Heart Failure Based on Network Pharmacology

OBJECTIVE To investigate the pharmacology mechanism of Astragalus membranaceus for heart failure based on network pharmacology. METHODS All of chemical components related to the Astragalus membranaceus were collected from the TCMSP database. The targets related to molecular compounds were found through the TCMSP, the targets related to heart failure were found through CTD online analysis platform. Thus, a component-target, target-protein interaction, and component-target-biological pathway network diagram was constructed. RESULTS Eighty seven candidate active molecules, 326 corresponding targets were obtained through network pharmacology screening, 36 targets related to heart failure. These targets could joint in 27 pathways. CONCLUSION The results preliminarily verify the activity components Astragalus membranaceus, and provides a good foundation for further study on the mechanism of action.