Research Progress of Anti-tumor Effects and Active Constituents of Actinidia Eriantha Benth. Root

OBJECTIVE To review the research progress of anti-tumor effects and active constituents of Actinidia eriantha Benth., in order to provide reference for the clinical application and further development of Actinidia eriantha Benth. root. METHODS The researches on anti-tumor and active constituents of Actinidia eriantha Benth. root from 1980 to 2018 were searched. The anti-tumor effect, mechanism and anti-tumor active ingredients were summarized and analyzed. RESULTS Actinidia eriantha Benth. root had various anti-tumor effects such as gastric cancer, liver cancer, nasopharyngeal carcinoma and cervical cancer. Its anti-tumor mechanism included regulating the expression of apoptosis-related genes, regulating immune regulation, arresting cell cycle and inhibiting proliferation and inducting apoptosis and necrosis, etc. Its anti-tumor active components were mainly triterpenoids. CONCLUSION Actinidia erantha Benth. root has good anti-tumor effect and high clinical value. It is necessary to strengthen its evidence-based medical data and in-depth study of anti-tumor active ingredients.