Establishment and Evaluation of Eye Irritation Standard in Cosmetic Formula by Using Chorioallantoic Membrane Vascular Assay

OBJECTIVE To establish eye irritation test standards for evaluating cosmetics by using chorioallantoic membrane vascular assay. METHODS The chorioallantoic membrane vascular assay(CAMVA) standard method of eye irritation by improving the evaluation system was established, and 20 batches of cosmetics of ten different types were evaluated. Compared the results with the Draize test and verified the feasibility of the CAMVA standard method. RESULTS The classification consistency of 20 batches of cosmetics on CAMVA and Draize test was 85% (17/20). CONCLUSION Established standards can be used in eye irritation test of cosmetics.