Study on the Urokinase in Maintaining Patency of the Peritoneal Drainage After Laparoscopic Appendectomy

OBJECTIVE To investigate the role of urokinase in maintaining patency of abdominal drainage tube after laparoscopic appendectomy. METHODS Fifty eight patients who placed drainage tube after laparoscopic appendectomy were divided into urokinase group and normal saline group by pairing. Urokinase group included 23 cases, were given once urokinase(500 U·mL^-1) within 24 h after laparoscopic appendectomy, sealing tube by 20-50 mL urokinase for 0.5 h. The normal saline group included 35 cases, was given once normal saline within 24 h after the operation, sealing tube by 20-50 mL normal saline for 0.5 h. According to the results of B-ultrasound examination, the results of dressing's exudation after extubating, the fluctuation of water column when hydrostatic pressure was measured, the flux in the 48 h after operation, the time of extubation and the sediment in the tube after extraction, two groups of experimental results were judged. Combined with drainage tube patency index, the significance of predicting the patency of drainage tube after 48 h of operation was explored. RESULTS The results of B-ultrasound examination in two groups, the results of dressing's exudation after extubating, the fluctuation of water column during hydrostatic pressure, the flux in the 48 h after operation and the time of extubation were compared, had significant statistical differences(P<0.05). Preoperative B-ultrasound examination in the urokinase group showed no significant effusion ratio, dry ratio of drainage tube dressing after extubation, water column fluctuation ratio at hydrostatic pressure and the 48 h flow rate was greater than that of normal saline group. And the extubation time of the urokinase group was shorter than that in the normal saline group. Logistic regression analys showed that the flux in the 48 h after operation had no statistical significance for predicting the patency of drainage tube. CONCLUSION Urokinase can effectively maintain the patency of abdominal drainage tube, facilitates early extubation, speed up the process of postoperative rapid recovery of patients.