Teicoplanin Dosage Regimens Optimization for Renal Insufficiency by NONMEN Method According to Expert Consensus

OBJECTIVE To explore the reasonable dose of teicoplanin for methicillin-resistant Staphylococcus aureus infection under different renal function status, and to optimize the expert consensus drug dosage plan. METHODS Two indices which were AUC_0-24/MIC ≥ 345 and trough concentration >30 mg·L^-1 were applied for the Monte Carlo simulations with NONMEM. The probability of target attainment and cumulative fraction of response were calculated among patients with three types of body weight and five types of renal dysfunction. RESULTS The result showed that the recommended loading dose of 6-12 mg·kg^-1 recommended by experts in different renal function states increased from 9.2 to 11.1 mg·kg^-1, with a maximum difference of 1.9 mg·kg^-1. CONCLUSION The Monte Carlo simulation results suggest that the dosing regimen recommended by the expert consensus of teicoplanin needs to be further clarified.