Clinical efficacy of Chinese Materia medica via multi-route treating ulcerative colitis and its effect on inflammatory factors

Objective To study the efficacy of Chinese material medica via multi-route treating ulcerative colitis and its effect on inflammatory factors. Methods A total of 136 patients with ulcerative colitis admitted from February 2016 to November 2017 were randomly divided into the control group (mesalazine oral combined enema treatment) and the study group (Chinese material medica decoction oral administration+Chinese material medica enema+Chinese material medica acupoint sticking treatment), 68 cases in each group. The levels of inflammatory factors, T lymphocyte subsets, colonoscopy and pathological examination scores, TCM symptoms (abdominal pain, diarrhea, mucus pus and bloody stool, re-score and total score), treatment efficiency and recurrence rate were analyzed before and after 12 weeks of treatment in both groups. Results After treatment, the levels of interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein in the study group were lower than the control group, and interleukin-10 was significantly higher than the control group (P<0.05). After treatment, the levels of CD₃⁺ and CD₈⁺ in the study group were significantly lower than the control group, CD₄⁺ and CD₄⁺/CD₈⁺ were significantly higher than the control group (P<0.05). The scores of colonoscopy and pathological examination in the study group were significantly better than the control group (P<0.05). The symptoms of TCM were significantly improved after treatment in both groups. The scores of TCM symptoms in the study group were significantly lower than the control group (P<0.05). The total effective rate of the study group was significantly higher than the control group (P<0.05). Six months after treatment, recurrence rate of the study group was significantly lower than that of the control group (P<0.05). Conclusion The clinical efficacy of Chinese material medica via multi-route treating ulcerative colitis is clear, which is beneficial to reduce inflammation, improve intestinal mucosal immune function, promote ulcer healing, improve TCM symptoms, and have high safety and low recurrence rate, which is worthy for clinical application.