Efficacy and Safety of Polysaccharide Iron Complex in the Treatment of Renal Anemia: A Meta-analysis

OBJECTIVE To systematically evaluate the efficacy and safety of polysaccharide iron complex for patients with renal anemia. METHODS PubMed, Embase, Cochrane Library, CNKI, WanFang Data and CBM were searched from their inception to May 2018. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.RESULTS A total of 7 RCTs involving 642 patients (354 patients in the test group and 288 patients in the control group) with renal anemia were included. The meta-analysis results showed that:compared with ferrous sulfate/ferrous succinate, the effective rate(P=0.02) and significant effective rate(P<0.000 01) of renal anemia in PIC were higher. PIC significantly increased hematocrit(P=0.02), serum ferritin(P=0.009), transferrin saturation(P<0.000 01), hematocrit(P=0.002), red blood cell(P=0.04). adverse reactions of PIC were rare and mild:nausea/vomiting(P<0.000 01), abdominal pain/burning sensation(P=0.000 1), constipation/diarrhea(P=0.000 2).CONCLUSION Compared with ferrous sulfate/ferrous succinate, polysaccharide iron complex is effective and safe in the treatment of renal anemia.