Effect of Shensong Yangxin Capsule Combined with Metoprolol and Moderate Aerobic Exercise on Inflammation and Oxidative Stress in Obese Patients with Atrial Fibrillation

OBJECTIVE To study the effects of Shensong Yangxin capsule combined with metoprolol and moderate aerobic exercise on obesity patients with atrial fibrillation and their effects on inflammation and oxidative stress factors. METHODS Eighty patients with obesity and atrial fibrillation were randomly divided into the control group and the experimental group (40 cases in each group). The control group received metoprolol treatment and moderate aerobic exercise based on conventional treatment. The experimental group received Shensong Yangxin capsule based on the control group. Continuous treatment 6 months. Observed and recorded the number and duration of atrial fibrillation before and after treatment, and the sinus rhythm maintenance effect after 1 month of treatment. Before and after treatment, echocardiography was performed to determine left atrial diameter(LAD), left ventricular ejection fraction(LVEF), and interventricular septum thickness (IVST). Six min walk test was adopted. Brain natriuretic peptide(BNP), N-terminal B brain natriuretic peptide (NT-proBNP) levels, hs-CRP, IL-6, TNF-α and APN inflammatory factors and Hcy oxidative stress factor levels were determined. RESULTS After treatment, the number and duration of atrial fibrillation in the experimental group were significantly lower than those before treatment and the control group(P<0.05); the sinus rhythm maintenance rate was significantly higher than that in the control group(P<0.05). The total effective rate of the experimental group was significantly higher than that of the control group(92.5% vs 75.0%, P<0.05). Compared with control group, LAD was significantly decreased(P<0.05), LVEF was significantly increased(P<0.05) in the experimental group; experimental BNP and NT-proBNP were significantly decreased(P<0.05). The IL-6, TNF-α, hs-CRP and APN inflammation indexes and oxidative stress index Hcy levels in the experimental group were significantly lower(P<0.05). CONCLUSION Shensong Yangxin capsule combined with moderate aerobic exercise and metoprolol can improve inflammation and oxidative stress in patients with obesity and atrial fibrillation, improve heart function and improve efficacy.