Effects of Whey Protein on Serum Albumin and Correlated Inflammatory Cytokines of Aepsis Patients with Hypoalbuminemia

OBJECTIVE To evaluate the clinical efficacy of whey protein on patients suffering from sepsis combined with hypoalbuminemia in emergency department and its influence on protein and inflammatory cytokines in serum. METHODS Ninty-two patients with sepsis and hypoalbuminemia were randomly divided into control group and observation group, 46 cases in each group. Control group was treated with basic treatment. Patients in observation group were treated with whey protein by enteral nutrition additionally. The clinical efficacy, the levels of protein and inflammatory cytokines in serum and adverse reactions were compared between the two groups. RESULTS The effective rate in observation group was 82.61%, significantly higher than 63.04% in control group (P<0.05). After treatment, the levels of albumin(ALB), prealbumin(PA) and total protein(TP) in observation group were significantly higher than those in control group (P<0.05). Inflammatory markers of D-dimer(D-D), C-reactive protein(CRP) and proealcitonin(PCT) in patients of the observation group were gradually decreased compared with the control group (P<0.05). During treatment, it showed no significant adverse reactions. CONCLUSION Whey protein has obvious curative effect and inhibit inflammatory response on sepsis combined with hypoalbuminemia, and it is suggested to apply in clinic.