Research Progress on the Mechanism of Resveratrol in the Prevention and Treatment of Alzheimer's Disease

Resveratrol is a polyphenol compound widely found in plants, such as grapes, polygonum cuspidatum, peanut, mulberry, cassia etc. Resveratrol exerts various biological activities including anti-aging, anti-inflammatory, antioxidant, scavenging free radicals, regulating autophagy, anti-apoptotic, estrogen-like effects, etc. In recent years, more and more researches show resveratrol can pass blood brain barrier to protect the nervous system, and can be applied to the prevention and treatment of Alzheimer's disease. In this paper, based on the pathogenesis of Alzheimer's disease, such as aggregation of amyloid β-peptide, hyperphosphorylation of tau protein, neuroinflammation and oxidative stress, the related research of resveratrol in Alzheimer's disease model are reviewed, which provide a reference for the further development of resveratrol.