Pharmaceutical Care of Clinical Pharmacist Involved in the Nasogastric Feeding of Sodium Valproate to Patients with Craniocerebral Injury

OBJECTIVE To investigate the mode of clinical pharmacist participating in the nasogastric feeding sodium valproate of patients with craniocerebral injury by therapeutic drug monitoring. METHODS An HPLC method was used to monitor the plasma concentration of valproic acid by nasogastric feeding and intravenous dripping sodium valproate in patients with craniocerebral injury. The effects of different dosage forms on the concentration of valproic acid and the role of clinical pharmacist in pharmaceutical care was studied. RESULTS The nasogastric feeding of sodium valproate significantly affected the plasma drug concentration. The plasma drug concentration couldn't reach the effective reference range. After the clinical pharmacist suggested, the nasogastric feeding of sodium valproate was changed to intravenous administration, the concentration of plasma drug increased, and the success rate increased. The difference was statistically significant (P<0.01). CONCLUSION In the medical team, clinical pharmacists shall make full use of their advantages in drug characteristics to carry out clinical pharmaceutical care.