Interaction of Voriconazole with Cyclosporin A or Tacrolimus in Recipients of Hematopoietic Stem Cell Transplantation

OBJECTIVE To investigate the interaction between voriconazole with cyclosporin A or tacrolimus, the steady-state concentration of voriconazole and immunosuppressive agents (cyclosporin A and tacrolimus) were detected in recipients of hematopoietic stem cell transplantation. METHODS The steady-state concentration data of voriconazole, cyclosporine A and tacrolimus in recipients of hematopoietic stem cell transplantation were retrospectively analyzed from 2016 June to December in hematology ward of Ningbo First Hospital. RESULTS When voriconazole combined with cyclosporin A, the steady-state concentration of cyclosporine A was increased by 41.55% (P<0.05), and the steady-state concentration of voriconazole decreased by 23.31%; When voriconazole combined with tacrolimus, the steady-state concentration of tacrolimus was increased by 17.52%, and the steady-state concentration of voriconazole decreased by 29.45% (P<0.05). CONCLUSION In the cases of combination drug therapy, it is recommended that the concentration of immunosuppressive agents and voriconazole shall be monitored closely. Only in this way, the medication can be used safely, effectively and reasonably.